Сотрудники

	ФИО	Должность, ученая степень, ученое звание	Телефон	Адрес электронной почты
1	Амстиславская Тамара Геннадьевна	Заведующая лабораторией, главный научный сотрудник, доктор биологических наук	(383) 373-01-85	Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра.
2	Калуев Алан Валерьевич	Главный научный сотрудник, доктор биологических наук	(383) 373-01-85	Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра.
3	Смирнова Кристина Вячеславовна	Лаборант-исследователь	(383) 373-01-85
4	Чижова Надежда Дмитриевна	Лаборант-исследователь	(383) 373-01-85

 

Основные направления исследований

Изучение нейробиологических и молекулярно-клеточных механизмов когнитивных и эмоциональных нарушений, а также нейродегенеративных процессов на экспериментальных моделях патогенеза центральной нервной системы у зебраданио (Danio rerio).

Избранные публикации

2023 год

• Kotova MM, Galstyan DS, Kolesnikova TO, de Abreu MS, Amstislavskaya TG, Strekalova T, Petersen EV, Yenkoyan KB, Demin KA, Kalueff AV. Understanding CNS Effects of Antimicrobial Drugs Using Zebrafish Models. Vet Sci. 2023 Jan 29;10(2):96. doi: 10.3390/vetsci10020096.

2022 год

• Bashirzade AAO, Cheresiz SV, Belova AS, Drobkov AV, Korotaeva AD, Azizi-Arani S, Azimirad A, Odle E, Gild EV, Ardashov OV, Volcho KP, Bozhko DV, Myrov VO, Kolchanova SM, Polovian AI, Galumov GK, Salakhutdinov NF, Amstislavskaya TG, Kalueff AV. MPTP-Treated Zebrafish Recapitulate 'Late-Stage' Parkinson's-like Cognitive Decline. Toxics. 2022 Feb 4;10(2):69. doi: 10.3390/toxics10020069.
• Bashirzade AA, Zabegalov KN, Volgin AD, Belova AS, Demin KA, de Abreu MS, Babchenko VY, Bashirzade KA, Yenkoyan KB, Tikhonova MA, Amstislavskaya TG, Kalueff AV. Modeling neurodegenerative disorders in zebrafish. Neurosci Biobehav Rev. 2022 Jul;138:104679. doi: 10.1016/j.neubiorev.2022.104679.
• Markova EV, Knyazheva MA, Tikhonova MA, Amstislavskaya TG. Structural and functional characteristics of the hippocampus in depressive-like recipients after transplantation of in vitro caffeine-modulated immune cells. Neurosci Lett. 2022 Aug 24;786:136790. doi: 10.1016/j.neulet.2022.136790.
• Tikhonova MA, Maslov NA, Bashirzade AA, Nehoroshev EV, Babchenko VY, Chizhova ND, Tsibulskaya EO, Akopyan AA, Markova EV, Yang YL, Lu KT, Kalueff AV, Aftanas LI, Amstislavskaya TG. A Novel Laser-Based Zebrafish Model for Studying Traumatic Brain Injury and Its Molecular Targets. Pharmaceutics. 2022 Aug 22;14(8):1751. doi: 10.3390/pharmaceutics14081751.

2021 год

• Fontana BD, Müller TE, Cleal M, de Abreu MS, Norton WHJ, Demin KA, Amstislavskaya TG, Petersen EV, Kalueff AV, Parker MO, Rosemberg DB. Using zebrafish (Danio rerio) models to understand the critical role of social interactions in mental health and wellbeing. Prog Neurobiol. 2022 Jan;208:101993. doi: 10.1016/j.pneurobio.2021.101993.
• de Abreu MS, Giacomini ACVV, Demin KA, Galstyan DS, Zabegalov KN, Kolesnikova TO, Amstislavskaya TG, Strekalova T, Petersen EV, Kalueff AV. Unconventional anxiety pharmacology in zebrafish: Drugs beyond traditional anxiogenic and anxiolytic spectra. Pharmacol Biochem Behav. 2021 Aug;207:173205. doi: 10.1016/j.pbb.2021.173205.
• В.Я. Бабченко, А.С. Белова, А.А. Баширзаде, М.А. Тихонова, К.А. Демин, К.Н. Забегалов, Е.В. Петерсен, А.В. Калуев, Т.Г. Амстиславская. Модели черепно-мозговой травмы у зебраданио (Zebrafish, Danio rerio). Российский физиологический журнал им. И.М. Сеченова. 2021, том 107, № 9, с. 1–19
• Wang J, Wang D, Hu G, Yang L, Liu Z, Yan D, Serikuly N, Alpyshov E, Demin KA, Strekalova T, Gil Barcellos LJ, Barcellos HHA, Amstislavskaya TG, de Abreu MS, Kalueff AV. The role of auditory and vibration stimuli in zebrafish neurobehavioral models. Behav Processes. 2021 Dec;193:104505. doi: 10.1016/j.beproc.2021.104505.
• Ting-Yi Renn, Chih-Ping Yang, Un-In Wu, Li-You Chen, Fu-Der Mai, Maria A. Tikhonova, Tamara G. Amstislavskaya, Wen-Chieh Liao, Che-Tong Lin, Yu-Chuan Liu, Hung-Ming Chang. Water composed of reduced hydrogen bonds activated by localized surface plasmon resonance effectively enhances anti-viral and anti-oxidative activities of melatonin. Chemical Engineering Journal. 427 (2022) 131626. https://doi.org/10.1016/j.cej.2021.131626
• Murilo S. de Abreu, Konstantin A. Demin, Ana C.V.V. Giacomini, Tamara G. Amstislavskaya, Tatyana Strekalova, Gleb O. Maslov, Yury Kositsin, Elena V. Petersen, Allan V. Kalueff. Understanding how stress responses and stress-related behaviors have evolved in zebrafish and mammals. Neurobiology of Stress. 15 (2021) 100405
• Маркова Е.В., Шевела Е.Я., Княжева М.А., Савкин И.В., Серенко Е.В., Ращупкин И.М., Амстиславская Т.Г., Останин А.А., Черных Е.Р. Влияние растворимых факторов макрофагов М2-фенотипа на поведенческий паттерн и продукцию цитокинов в головном мозге депрессивноподобных мышей. БЭБиМ. 2021. Т. 172, № 9. С. 334-338.
• de Abreu MS, Demin KA, Giacomini ACVV, Amstislavskaya TG, Strekalova T, Maslov GO, Kositsin Y, Petersen EV, Kalueff AV. Understanding how stress responses and stress-related behaviors have evolved in zebrafish and mammals. Neurobiol Stress. 2021 Sep 29;15:100405. doi: 10.1016/j.ynstr.2021.100405. PMID: 34722834; PMCID: PMC8536782.
• de Abreu MS, Giacomini ACVV, Genario R, Demin KA, Amstislavskaya TG, Costa F, Rosemberg DB, Sneddon LU, Strekalova T, Soares MC, Kalueff AV. Understanding early-life pain and its effects on adult human and animal emotionality: Translational lessons from rodent and zebrafish models. Neurosci Lett. 2022 Jan 18;768:136382. doi: 10.1016/j.neulet.2021.136382. Epub 2021 Nov 30. PMID: 34861343.
• Yang ST, Hung HY, Ro LS, Liao MF, Amstislavskaya TG, Tikhonova MA, Yang YL, Lu KT. Chronic Administration of 7,8-DHF Lessens the Depression-like Behavior of Juvenile Mild Traumatic Brain Injury Treated Rats at Their Adult Age. Pharmaceutics. 2021 Dec 16;13(12):2169. doi: 10.3390/pharmaceutics13122169. PMID: 34959450.

2020 год

• Cheresiz S. V., Volgin A. D., Kokorina Evsyukova A., Bashirzade A.A.O., Demin K. A., de Abreu M. S., Amstislavskaya T. G., Kalueff A. V. Understanding neurobehavioral genetics of zebrafish // J Neurogenet. Vol. 34, N2. P. 203?215 (doi: 10.1080/01677063.2019.1698565).
• de Abreu M.S., Genario R., Giacomini A.C.V.V., Demin K.A., Lakstygal A.M., Amstislavskaya T.G., Fontana B.D., Parker M.O., Kalueff A.V. Zebrafish as a Model of Neuro-developmental Disorders. Neuroscience. 2020 Vol.445. P.3-11 (doi: 10.1016/j.neuroscience.2019.08.034).
• de Abreu M.S., Giacomini A.C.V.V., Genario R., Rech N., Carboni J., Lakstygal A.M., Amstislavskaya T.G., Demin K.A., Leonard B.E., Vlok M., Harvey B.H., Piato A., Barcellos L.J.G., Kalueff A.V. Non-pharmacological and pharmacological approaches for psychiatric disorders: Re-appraisal and insights from zebrafish models // Pharmacol Biochem Behav. 2020. Vol.193. Art 172928 (doi: 10.1016/j.pbb.2020.172928).
• de Abreu MS C.V.V., Giacomini A., Genario R., Fontana B.D., Parker M.O., Marcon L., Scolari N., Bueno B., Demin K.A., Galstyan D., Kolesnikova T. O., Amstislavskaya T. G., Zabegalov K.N., Strekalova T., Kalueff A. V. Zebrafish models of impulsivity and impulse control disorders // Eur J Neurosci. 2020. Vol. 52, N 10. P. 4233-4248 (doi:10.1111/ejn.14893).
• Demin K. A , Lakstygal A. M., Volgin A. D., de Abreu M. S., Genario R., Alpyshov E. T., Serikuly N., Wang D-M., Wang J-T., Yan D., Wang M-Y., Yang L-E., Hu G., Bytov M., Zabegalov K. A., Zhdanov A., Harvey B. H., Costa F., Rosemberg D. B., Leonard B. E., Fontana B. D., Cleal M., Parker M. O., Wang J., Song C., Amstislavskaya T. G., Kalueff A. V. Cross-species Analyses of Intra-species Behavioral Differences in Mammals and Fish // Neuroscience. Vol. 429. P. 33–45 (doi:10.1016/j.neuroscience.2019.12.035).
• Demin K. A., Lakstygal A. M., Krotova N. A., Masharsky A., Tagawa N., Chernysh M. V., Ilyin N. P., Taranov A. S., Galstyan D. S., Derzhavina K. A., Levchenko N. A., Kolesnikova T. O., Mor M. S., Vasyutina M. L., Efimova E. V., Katolikova N., Prjibelski A. D., Gainetdinov R. R., de Abreu M. S., Amstislavskaya T. G., Strekalova T., Kalueff A. V. Understanding complex dynamics of behavioral, neuro-chemical and transcriptomic changes induced by prolonged chronic unpredictable stress in zebrafish // Sci Rep. 2020. Vol.10, N1. Art.19981 (doi: 10.1038/s41598-020-75855-3).
• Wang D., Yang L., Wang J., Hu G., Liu Z., Yan D., Serikuly N., Alpyshov E., Demin K.A., Galstyan D., Strekalova T., de Abreu M.S., Amstislavskaya T.G., Kalueff A.V. Behavioral and physiological effects of acute and chronic kava exposure in adult zebrafish //Neurotoxicol Teratol. 2020. Vol. 79. Art. 106881 (doi:10.1016/j.ntt.2020.106881).
• Wang J., Wang D., Hu G., Yang L., Yan D., Wang M., Serikuly N., Alpyshov E., Amstislavskaya T. G., Demin K. A., de Abreu M. S., Zabegalov K. N., Kalueff A. V. A new method for vibration-based neurophenotyping of zebrafish // J Neurosci Methods. 2020. Vol. 333. Art 108563 (doi:10.1016/j.jneumeth.2019.108563).
• Yang L., Wang J., Wang D., Hu G., Liu Z., Yan D., Serikuly N., Alpyshov E.T., Demin K.A., Strekalova T., de Abreu M.S., Song C., Kalueff A.V. Delayed behavioral and genomic responses to acute combined stress in zebrafish, potentially relevant to PTSD and other stress-related disorders: Focus on neuroglia, neuroinflammation, apoptosis and epigenetic modulation // Behav Brain Res. 2020. Vol.389. Art.112644 (doi: 10.1016/j.bbr.2020.112644)

2019 год

• Demin K. A., Sysoev M., Chernysh M. V., Savva A. K., Koshiba M., Wappler-Guzzetta E. A., Song C., De Abreu M. S., Leonard B., Parker M. O., Harvey B. H., Tian L., Vasar E., Strekalova T., Amstislavskaya T. G., Volgin A. D., Alpyshov E. T., Wang D., Kalueff A. V. Animal models of major depressive disorder and the implications for drug discovery and development. // Expert Opin Drug Discov. – 2019. – Vol. 4, N4. – Pp. 365-378 (doi: 10.1080/17460441.2019.1575360).
• Fontana B. D., Franscescon F., Rosemberg D. B., Norton W. H. J., Kalueff A. V., Parker M. O. Zebrafish models for attention deficit hyperactivity disorder (ADHD) // Neurosci Biobehav Rev. – 2019. – Vol. 100. – Pp. 9-18 (doi: 10.1016/j.neubiorev.2019.02.009)
• Genario R., Giacomini A. C. V. V., Demin K. A., Dos Santos B. E., Marchiori N. I., Volgin A. D., Bashirzade A., Amstislavskaya T. G., de Abreu M. S., Kalueff A. V. The evolutionarily conserved role of melatonin in CNS disorders and behavioral regulation: translational lessons from zebrafish // Neurosci Biobehav Rev. – 2019. – Vol. 99. – Pp. 117-127 (doi: 10.1016/j.neubiorev.2018.12.025).
• Volgin A.D., Yakovlev O.A., Demin K.A., de Abreu M.S., Alekseeva P.A., Friend A.J., Lakstygal A.M., Amstislavskaya T.G., Bao W., Song C., Kalueff A.V. Zebrafish models for personalized psychiatry: Insights from individual, strain and sex differences, and modeling gene x environment interactions. J Neurosci Res. – 2019. – Vol. 97, N4. – Pp. 402-413. doi: 10.1002/jnr.24337.
• Zabegalov K. N., Khatsko S. L., Lakstygal A. M., Demin K. A., Cleal M., Fontana B. D., McBride S. D., Harvey B. H., de Abreu M. S., Parker M. O., Kalueff A. V. Abnormal repetitive behaviors in zebrafish and their relevance to human brain disorders // Behav Brain Res. – 2019. – Vol. 367. – Pp. 101-110 (doi: 10.1016/j.bbr.2019.03.044).
• Кротова Н. А., Лакстыгал А. М., Таранов А. С., Ильин Н. П., Бытов М. В., Волгин А. Д., Амстиславская Т. Г., Демин К. А., Калуев А. В. Зебраданио (Zebrafish) как новая перспективная модель в трансляционной нейробиологии // Российский физиологический журнал им. И. М. Сеченова. - 2019. - Т. 105, № 11. - С. 1417 – 1435 (doi: 10.1134/S0869813919110062).

2018 год

• de  Abreu M. S., Friend A. J., Amstislavskaya T. G., Kalueff A. V. Commentary: Establishing zebrafish as a model to study the anxiolytic effects of scopolamine // Frontiers in Pharmacology. – 2018. – Vol. 9. - P.293 (doi: 10.3389/fphar.2018.00293). https://www.frontiersin.org/articles/10.3389/fphar.2018.00293/full
• Zabegalov K. N., Kolesnikova T. O., Khatsko S. L., Volgin A. D., Yakovlev O. A., Amstislavskaya T. G., Alekseeva P. A., Meshalkina D. A., Friend A. J., Bao W., Demin K. A., Gainetdinov R. R., Kalueff A. V. Understanding antidepressant discontinuation syndrome (ADS) through preclinical experimental models // European Journal of Pharmacology. – 2018. – Vol. 829. – P. 129-140 (doi: 10.1016/j.ejphar.2018.04.003). https://www.ncbi.nlm.nih.gov/pubmed/29627310
• Mezzomo N. J., Fontana B. D., Kalueff A. V., Barcellos L. J. G., Rosemberg D. B. Understanding taurine CNS activity using alternative zebrafish models // Neuroscience and Biobehavioral Reviews. – 2018. – Vol. 90 – P. 471-485 (doi: 10.1016/j.neubiorev.2018.04.012).
• Lakstygal A. M., de Abreu M. S., Kalueff A. V. Zebrafish models of epigenetic regulation of CNS functions // Brain Research Bulletin. – 2018. – Vol. 142. – P.:344-351 (doi: 10.1016/j.brainresbull.2018.08.022).
• Volgin A. D., Yakovlev O. V., Demin K. A., Abreu M. S., Rosemberg D. B., Meshalkina D. A., Alekseeva P. A., Friend A. J., Amstislavskaya T. G., Kalueff A. V. Understanding the role of environmental enrichment in zebrafish neurobehavioral models // Zebrafish. – 2018. – Vol. 15, № 5. – P. 425-432 (https://doi.org/10.1089/zeb.2018.1592).
• de Abreu M. S., Friend A. J., Demin K. A., Amstislavskaya T. G., Bao W., Kalueff A. V. Zebrafish models: do we have valid paradigms for depression? // Journal of Pharmacolological and Toxicological Methods. – 2018. – Vol. 94, Pt.2. – P. 16-22 (https://doi.org/10.1016/j.vascn.2018.07.002).

2017 год

• Ragaeva DS, Tikhonova MA, Petrova OM, Igonina TN, Rozkova IN, Brusentsev EY, Amstislavskaya TG, Amstislavsky SY. Neonatal reflexes and behavior in hypertensive rats of ISIAH strain. Physiol Behav. 2017 Jun 1;175:22-30. doi: 10.1016/j.physbeh.2017.03.026
• Tikhonova MA, Ho SC, Akopyan AA, Kolosova NG, Weng JC, Meng WY, Lin CL, Amstislavskaya TG, Ho YJ. Neuroprotective Effects of Ceftriaxone Treatment on Cognitive and Neuronal Deficits in a Rat Model of Accelerated Senescence. Behav Brain Res. 2017 May 6;330:8-16. doi: 10.1016/j.bbr.2017.05.002
• Ranneva SV, Pavlov KS, Gromova AV, Amstislavskaya TG, Lipina TV. Features of emotional and social behavioral phenotypes of calsyntenin2 knockout mice. Behav Brain Res. 2017 Aug 14; 332:343-354. doi: 10.1016/j.bbr.2017.06.029
• Wu YJ, Hsu MT, Ng MC, Amstislavskaya TG, Tikhonova MA, Yang YL, Lu KT. Fragile X Mental Retardation-1 Knockout Zebrafish Shows Precocious Development in Social Behavior. Zebrafish. 2017 Oct;14(5):438-443. doi: 10.1089/zeb.2017.1446
• Wu YJ, Chen YL, Tang TH, Ng MC, Amstislavskaya TG, Tikhonova MA, Yang YL, Lu KT. Unilateral stimulation of the lateral division of the dorsal telencephalon induces synaptic plasticity in the bilateral medial division of zebrafish. Sci Rep. 2017 Aug 22;7(1):9096. doi: 10.1038/s41598-017-08093-9

2016 год

• Wu HF, Amstislavskaya TG, Chen PH, Wu TF, Chen YH, Jen CP. Preconcentration-enhanced Immunosensing for Whole Human Cancer Cell Lysate based on a Nanofluidic Preconcentrator. BioChip J. 2016, 10(3): 159-166 DOI 10.1007/s13206-016-0203-y
• Weng JC, Tikhonova MA, Chen JH, Shen MS, Meng WY, Chang YT, Chen KH, Liang KC, Hung CS, Amstislavskaya TG, Ho YJ. Ceftriaxone prevents the neurodegeneration and decreased neurogenesis seen in a Parkinson's disease rat model: An immunohistochemical and MRI study. Behav Brain Res. 2016, 305:126-139. doi: 10.1016/j.bbr.2016.02.034
• Chen YH, Wu HF, Amstislavskaya TG, Li CY, Jen CP. A simple electrokinetic protein preconcentrator utilizing nano-interstices. Biomicrofluidics 10, 024121 (2016); doi: 10.1063/1.4946768 View online: http://dx.doi.org/10.1063/1.4946768

2015 год

• Lu KT, Huang TC, Wang JY, You YS, Chou JL, Chan MW, Wo PY, Amstislavskaya TG, Tikhonova MA, Yang YL. NKCC1 mediates traumatic brain injury-induced hippocampal neurogenesis through CREB phosphorylation and HIF-1? expression. Pflugers Arch, (Pflugers Archiv: European Journal of Physiology), 2015 Aug;467(8):1651-61. doi: 10.1007/s00424-014-1588-x. 
• Jen CP, Amstislavskaya TG, Chen KF, Chen YH. Sample preconcentration utilizing nanofractures generated by junction gap breakdown assisted by self-assembled monolayer of gold nanoparticles. PLoS One. 2015 May 13;10(5):e0126641. doi: 10.1371/journal.pone.0126641. eCollection 2015.
• Tikhonova MA, Romaschenko AV, Akulov AE, Ho YJ, Kolosova NG, Moshkin MP, Amstislavskaya TG. Comparative study of perception and processing of socially or sexually significant odor information in male rats with normal or accelerated senescence using fMRI. Behav Brain Res. 2015, V. 294, P. 89–94. doi: 10.1016/j.bbr.2015.08.001
• Huang CK, YT Chang, TG Amstislavskaya, MA Tikhonova, CL Lin, CS Hung, TJ Lai, YJ Ho. Synergistic effects of ceftriaxone and erythropoietin on neuronal and behavioral deficits in an MPTP-induced animal model of Parkinson’s disease dementia. Behav Brain Res. 2015, V.294, P.198-207
• Tikhonova M.A., Amstislavskaya T.G. Phenotyping the males of mouse and rat strains with genetically defined behavioral disturbances in a model of sexual activation. Russian Journal of Genetics: Applied Research, 2016, V6, N4, P410-416. doi: 10.1134/S2079059716040201. http://link.springer.com/article/10.1134/S2079059716040201?view=classic

2014 год

• Hung YT, Tikhonova MA, Ding SJ, Kao PF, Lan HH, Liao JM, Chen JH, Amstislavskaya TG, Ho YJ. Effects of chronic treatment with diosgenin on bone loss in a D-galactose-induced aging rat model. The Chinese Journal of Physiology, 2014, V. 57(3), P.121-127. doi: 10.4077/CJP.2014.BAC199. 
• Tikhonova MA, Yu CH, Kolosova NG, Gerlinskaya LA, Maslennikova SO, Yudina AV, Amstislavskaya TG, Ho YJ. Comparison of behavioral and biochemical deficits in rats with hereditary defined or D-galactose-induced accelerated senescence: evaluating the protective effects of diosgenin. Pharmacology, Biochemistry and Behavior, 2014, V.120, P.7-16
• Ho SC, Hsu CC, Yu CH, Huang WN, Tikhonova MA, Ho MC, Wu FY, Amstislavskaya TG, Ho YJ. Measuring attention in a Parkinson's disease rat model using the 5-arm maze test. Physiol Behav. 2014, V.130 C.176-181
• Ho SC, Hsu CC, Pawlak CR, Tikhonova MA, Lai TJ, Amstislavskaya TG, Ho YJ. Effects of ceftriaxone on the behavioral and neuronal changes in an MPTP-induced Parkinson's disease rat model. Behav Brain Research, 2014, 268 C.177-184
• Jen CP, Amstislavskaya TG, Kuo CC, Chen YH. Protein preconcentration using nanofractures generated by nanoparticle-assisted electric breakdown at junction gaps. PLoS One. 2014 Jul 15;9(7):e102050. doi: 10.1371/journal.pone.0102050. eCollection 2014
• Ko MC, Lee MC, Amstislavskaya TG, Tikhonova MA, Yang YL, Lu KT. Inhibition of NKCC1 Attenuated Hippocampal LTP Formation and Inhibitory Avoidance in Rat. PLoS One. 2014 Nov 4;9(11):e106692. doi: 10.1371/journal.pone.0106692. eCollection 2014

Основное оборудование